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A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function
Joint Authors
Wen, Zhiyong
Liu, Weihua
Li, Xing
Chen, Weiguo
Liu, Zhice
Wen, Jianbo
Liu, Zhiping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nrf2 (NF-E2-related factor 2) is a master regulator of cellular oxidative levels against environmental stresses.
Nrf2 induces the expression of metabolic detoxification and antioxidant enzymes to eliminate reactive oxygen species (ROS).
The gastrointestinal tract is a key source of ROS.
Intestinal barrier is critical to maintain the healthy steady state of the human gastrointestinal tract.
Nrf2 has been shown to play important roles in maintaining the integrity of intestinal mucosal barrier.
Here, we made a systematic review on the roles of Nrf2 in maintaining intestinal barrier, including the following: (1) NRF2 reduced intestinal mucosal injury by suppressing oxidative stress; (2) NRF2 decreased intestinal inflammation by inhibiting the inflammatory pathway; (3) NRF2 affected intestinal tight junction proteins and apoptosis of cells to regulate intestinal permeability; (4) NRF2 affected T cell differentiation and functions; (5) the crossregulation between the KEAP1-NRF2 pathway and autophagy controlled intestinal oxidative stress.
American Psychological Association (APA)
Wen, Zhiyong& Liu, Weihua& Li, Xing& Chen, Weiguo& Liu, Zhice& Wen, Jianbo…[et al.]. 2019. A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202362
Modern Language Association (MLA)
Wen, Zhiyong…[et al.]. A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1202362
American Medical Association (AMA)
Wen, Zhiyong& Liu, Weihua& Li, Xing& Chen, Weiguo& Liu, Zhice& Wen, Jianbo…[et al.]. A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202362