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Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke
Joint Authors
Armstrong, Lawrence E.
Lee, Elaine C.
Armstrong, Elizabeth M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-33, 33 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-16
Country of Publication
Egypt
No. of Pages
33
Main Subjects
Abstract EN
Exertional heatstroke (EHS) is a medical emergency that cannot be predicted, requires immediate whole-body cooling to reduce elevated internal body temperature, and is influenced by numerous host and environmental factors.
Widely accepted predisposing factors (PDF) include prolonged or intense exercise, lack of heat acclimatization, sleep deprivation, dehydration, diet, alcohol abuse, drug use, chronic inflammation, febrile illness, older age, and nonsteroidal anti-inflammatory drug use.
The present review links these factors to the human intestinal microbiota (IM) and diet, which previously have not been appreciated as PDF.
This review also describes plausible mechanisms by which these PDF lead to EHS: endotoxemia resulting from elevated plasma lipopolysaccharide (i.e., a structural component of the outer membrane of Gram-negative bacteria) and tissue injury from oxygen free radicals.
We propose that recognizing the lifestyle and host factors which are influenced by intestine-microbial interactions, and modifying habitual dietary patterns to alter the IM ecosystem, will encourage efficient immune function, optimize the intestinal epithelial barrier, and reduce EHS morbidity and mortality.
American Psychological Association (APA)
Armstrong, Lawrence E.& Lee, Elaine C.& Armstrong, Elizabeth M.. 2018. Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke. Journal of Sports Medicine،Vol. 2018, no. 2018, pp.1-33.
https://search.emarefa.net/detail/BIM-1202365
Modern Language Association (MLA)
Armstrong, Lawrence E.…[et al.]. Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke. Journal of Sports Medicine No. 2018 (2018), pp.1-33.
https://search.emarefa.net/detail/BIM-1202365
American Medical Association (AMA)
Armstrong, Lawrence E.& Lee, Elaine C.& Armstrong, Elizabeth M.. Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke. Journal of Sports Medicine. 2018. Vol. 2018, no. 2018, pp.1-33.
https://search.emarefa.net/detail/BIM-1202365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202365