Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy
Joint Authors
Yang, Chul Woo
Chung, Byung Ha
Luo, Kang
Lim, Sun Woo
Quan, Yi
Cui, Sheng
Shin, Yoo Jin
Ko, Eun Jeong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Calcineurin inhibitors (CNIs) are the most popular immunosuppressants in organ transplantation, but nephrotoxicity is a major concern.
The common mechanism underlying chronic CNI nephropathy is oxidative stress, and the process of chronic CNI nephropathy is similar to that of aging.
Current studies provide evidence that antiaging Klotho protein plays an important role in protecting against oxidative stress, and its signaling is a target for preventing oxidative stress-induced aging process.
In this review, we focus on the association between Klotho and oxidative stress and the protective mechanism of action of Klotho against oxidative stress in chronic CNI nephropathy.
In addition, we discuss the delivery strategy for Klotho in CNI-induced nephropathy.
American Psychological Association (APA)
Luo, Kang& Lim, Sun Woo& Quan, Yi& Cui, Sheng& Shin, Yoo Jin& Ko, Eun Jeong…[et al.]. 2019. Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202381
Modern Language Association (MLA)
Luo, Kang…[et al.]. Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1202381
American Medical Association (AMA)
Luo, Kang& Lim, Sun Woo& Quan, Yi& Cui, Sheng& Shin, Yoo Jin& Ko, Eun Jeong…[et al.]. Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202381