Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle
Joint Authors
Rizzuto, Rosario
Gherardi, Gaia
Di Marco, Giulia
Mammucari, Cristina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy is responsible for the maintenance of skeletal muscle homeostasis, thanks to the removal of aberrant and dysfunctional macromolecules and organelles.
During fasting, increased autophagy ensures the maintenance of the amino acid pool required for energy production.
The activity of the mitochondrial Ca2+ uniporter (MCU), the highly selective channel responsible for mitochondrial Ca2+ uptake, controls skeletal muscle size, force, and nutrient utilization.
Thus, both autophagy and mitochondrial Ca2+ accumulation play a pivotal role to maintain muscle homeostasis and to sustain muscle function.
Here, we address whether, in skeletal muscle, mitochondrial Ca2+ uptake and autophagy are mutually related.
Muscle-restricted MCU silencing partially inhibits the autophagy flux.
Moreover, skeletal muscle-specific deletion of the essential autophagy gene Atg7, known to cause the accumulation of dysfunctional mitochondria, drastically reduces mitochondrial Ca2+ accumulation.
Thus, a vicious cycle takes place, in which reduced MCU activity hampers the autophagic flux, and loss of autophagy further impairs mitochondrial Ca2+ signaling.
American Psychological Association (APA)
Gherardi, Gaia& Di Marco, Giulia& Rizzuto, Rosario& Mammucari, Cristina. 2019. Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202386
Modern Language Association (MLA)
Gherardi, Gaia…[et al.]. Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202386
American Medical Association (AMA)
Gherardi, Gaia& Di Marco, Giulia& Rizzuto, Rosario& Mammucari, Cristina. Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202386