Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?
Joint Authors
Bilska-Wilkosz, Anna
Kotańska, Magdalena
Górny, Magdalena
Filipek, Barbara
Iciek, Małgorzata
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The exogenous lipoic acid (LA) is successfully used as a drug in the treatment of many diseases.
It is assumed that after administration, LA is transported to the intracellular compartments and reduced to dihydrolipoic acid (DHLA) which is catalyzed by NAD(P)H-dependent enzymes.
The purpose of this study was to investigate whether LA can attenuate cardiovascular disturbances induced by ethanol (EtOH) and disulfiram (DSF) administration separately or jointly in rats.
For this purpose, we measured systolic and diastolic blood pressure, recorded electrocardiogram (ECG), and estimated mortality of rats.
We also studied the activity of aldehyde dehydrogenase (ALDH) in the rat liver.
It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication.
The administration of EtOH, LA, and DSF separately or jointly affected the ALDH activity in the rat liver since a significant decrease in the activity of the enzyme was observed in all treatment groups.
The results indicating that LA is an inhibitor of ALDH activity are very surprising.
American Psychological Association (APA)
Bilska-Wilkosz, Anna& Kotańska, Magdalena& Górny, Magdalena& Filipek, Barbara& Iciek, Małgorzata. 2019. Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202460
Modern Language Association (MLA)
Bilska-Wilkosz, Anna…[et al.]. Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202460
American Medical Association (AMA)
Bilska-Wilkosz, Anna& Kotańska, Magdalena& Górny, Magdalena& Filipek, Barbara& Iciek, Małgorzata. Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202460