Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions
Joint Authors
Guimarães, Luciana Lopes
Moreira, Letícia Parada
Lourenço, Bárbara Faria
Toma, Walber
Zângaro, Renato Amaro
Pacheco, Marcos Tadeu Tavares
Silveira, Landulfo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This work employed a quantitative model based on Raman spectroscopy and principal component regression (RS/PCR) to quantify the active ingredient dipyrone (metamizole) in commercially available formulations as an analytical methodology for quality control in the pharmaceutical industry.
Raman spectra were collected using a dispersive Raman spectrometer (830 nm, 250 mW excitation, and 20 s exposure time) coupled to a Raman probe.
Solutions of dipyrone diluted in water in the range of 80 to 120% of the concentration of commercial formulations (500 mg/mL) were used to develop a calibration model based on PCR to obtain the figures of merit for class I validation from the Brazilian Sanitary Surveillance Agency (ANVISA, RE no.
899/2003).
This spectral model was then used to predict the concentration of dipyrone in commercial formulations from distinct brands with 500 mg/mL.
A prediction error of 6.5 mg/mL (1.3%) was found for this PCR model using the diluted samples.
Commercial formulations had predicted concentrations with a difference below 5.0% compared to the label concentration, indicating the applicability of Raman spectroscopy for quality control in the final product.
American Psychological Association (APA)
Guimarães, Luciana Lopes& Moreira, Letícia Parada& Lourenço, Bárbara Faria& Toma, Walber& Zângaro, Renato Amaro& Pacheco, Marcos Tadeu Tavares…[et al.]. 2018. Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions. Journal of Spectroscopy،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1202480
Modern Language Association (MLA)
Guimarães, Luciana Lopes…[et al.]. Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions. Journal of Spectroscopy No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1202480
American Medical Association (AMA)
Guimarães, Luciana Lopes& Moreira, Letícia Parada& Lourenço, Bárbara Faria& Toma, Walber& Zângaro, Renato Amaro& Pacheco, Marcos Tadeu Tavares…[et al.]. Multivariate Method Based on Raman Spectroscopy for Quantification of Dipyrone in Oral Solutions. Journal of Spectroscopy. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1202480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202480