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Cellular Therapeutics for Heart Failure: Focus on Mesenchymal Stem Cells
Joint Authors
Harris, David
Pandey, Amitabh C.
Lancaster, Jordan J.
Goldman, Steven
Juneman, Elizabeth
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Resulting from a various etiologies, the most notable remains ischemia; heart failure (HF) manifests as the common end pathway of many cardiovascular processes and remains among the top causes for hospitalization and a major cause of morbidity and mortality worldwide.
Current pharmacologic treatment for HF utilizes pharmacologic agents to control symptoms and slow further deterioration; however, on a cellular level, in a patient with progressive disease, fibrosis and cardiac remodeling can continue leading to end-stage heart failure.
Cellular therapeutics have risen as the new hope for an improvement in the treatment of HF.
Mesenchymal stem cells (MSCs) have gained popularity given their propensity of promoting endogenous cellular repair of a myriad of disease processes via paracrine signaling through expression of various cytokines, chemokines, and adhesion molecules resulting in activation of signal transduction pathways.
While the exact mechanism remains to be completely elucidated, this remains the primary mechanism identified to date.
Recently, MSCs have been incorporated as the central focus in clinical trials investigating the role how MSCs can play in the treatment of HF.
In this review, we focus on the characteristics of MSCs that give them a distinct edge as cellular therapeutics and present results of clinical trials investigating MSCs in the setting of ischemic HF.
American Psychological Association (APA)
Pandey, Amitabh C.& Lancaster, Jordan J.& Harris, David& Goldman, Steven& Juneman, Elizabeth. 2017. Cellular Therapeutics for Heart Failure: Focus on Mesenchymal Stem Cells. Stem Cells International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1202540
Modern Language Association (MLA)
Pandey, Amitabh C.…[et al.]. Cellular Therapeutics for Heart Failure: Focus on Mesenchymal Stem Cells. Stem Cells International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1202540
American Medical Association (AMA)
Pandey, Amitabh C.& Lancaster, Jordan J.& Harris, David& Goldman, Steven& Juneman, Elizabeth. Cellular Therapeutics for Heart Failure: Focus on Mesenchymal Stem Cells. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1202540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202540