Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls
Joint Authors
Kasakin, Marat F.
Rogachev, Artem D.
Predtechenskaya, Elena V.
Zaigraev, Vladimir J.
Koval, Vladimir V.
Pokrovsky, Andrey G.
Source
Multiple Sclerosis International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS); nevertheless, it takes a considerable amount of time to make a clinical decision.
Amino acid and fatty acid metabolic pathways are disturbed in MS, and this information could be useful for diagnosis.
The aim of our study was to find changes in amino acid and acylcarnitine plasma profiles for distinguishing patients with multiple sclerosis from healthy controls.
We have applied a targeted metabolomics approach based on tandem mass-spectrometric analysis of amino acids and acylcarnitines in dried plasma spots followed by multivariate statistical analysis for discovery of differences between MS (n=16) and control (n=12) groups.
It was found that partial least square discriminant analysis yielded better group classification as compared to principal component linear discriminant analysis and the random forest algorithm.
All the three models detected noticeable changes in the amino acid and acylcarnitine profiles in the MS group relative to the control group.
Our results hold promise for further development of the clinical decision support system.
American Psychological Association (APA)
Kasakin, Marat F.& Rogachev, Artem D.& Predtechenskaya, Elena V.& Zaigraev, Vladimir J.& Koval, Vladimir V.& Pokrovsky, Andrey G.. 2020. Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls. Multiple Sclerosis International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1202579
Modern Language Association (MLA)
Kasakin, Marat F.…[et al.]. Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls. Multiple Sclerosis International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1202579
American Medical Association (AMA)
Kasakin, Marat F.& Rogachev, Artem D.& Predtechenskaya, Elena V.& Zaigraev, Vladimir J.& Koval, Vladimir V.& Pokrovsky, Andrey G.. Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls. Multiple Sclerosis International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1202579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202579