Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans
Joint Authors
Abdul-Aziz, Noraishah Mydin
Marwan, Ahmed I.
Mohd-Zin, Siti W.
Abou Chaar, Mohamad K.
Ahmad-Annuar, Azlina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
29
Main Subjects
Abstract EN
Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs).
It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects.
In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse.
Our understanding of spina bifida is currently limited to the observations we make in mouse models, which reflect complete or targeted knockouts of genes, which perturb the whole gene(s) without taking into account the issue of haploinsufficiency, which is most prominent in the human spina bifida condition.
We thus conclude that the need to study spina bifida in all its forms, both aperta and occulta, is more indicative of the spina bifida in surviving humans and that the measure of deterioration arising from caudal neural tube defects, more commonly known as spina bifida, must be determined by the level of the lesion both in mouse and in man.
American Psychological Association (APA)
Mohd-Zin, Siti W.& Marwan, Ahmed I.& Abou Chaar, Mohamad K.& Ahmad-Annuar, Azlina& Abdul-Aziz, Noraishah Mydin. 2017. Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans. Scientifica،Vol. 2017, no. 2017, pp.1-29.
https://search.emarefa.net/detail/BIM-1202629
Modern Language Association (MLA)
Mohd-Zin, Siti W.…[et al.]. Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans. Scientifica No. 2017 (2017), pp.1-29.
https://search.emarefa.net/detail/BIM-1202629
American Medical Association (AMA)
Mohd-Zin, Siti W.& Marwan, Ahmed I.& Abou Chaar, Mohamad K.& Ahmad-Annuar, Azlina& Abdul-Aziz, Noraishah Mydin. Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans. Scientifica. 2017. Vol. 2017, no. 2017, pp.1-29.
https://search.emarefa.net/detail/BIM-1202629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202629