Synthesis, Structure, and Cyclocondensation of the 4,4,4-Trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)-1-butanone with Hydroxylamine and Hydrazine
Joint Authors
Flores, Alex F. C.
Kuhn, Bruna P.
Flores, Darlene C.
Pereira, Mariano A.
Balliano, Tatiane L.
da Silva, Givanildo S.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The synthesis of 4,4,4-trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)butan-1-one (3) through acylation of 1,1-dimethoxy-1-(thien-2-yl)propane (1) with trifluoroacetic anhydride and its reactions with hydroxylamine and hydrazine was investigated.
X-ray structural analysis of new trifluoromethyl-substituted dielectrophile 3 revealed that this hydrate exists as a racemate with inter- and intramolecular O-H·O bonds.
The crystal structure shows alignment along axis b of pair molecules with the same configuration of the O2-H·O1 bond.
For 5(3)-trifluoromethyl-4-methyl-3(5)-(thien-2-yl)-1H-pyrazole (4), obtained via cyclocondensation of precursor 2 and hydrazine hydrochloride, X-ray structural analysis indicated that its rings are almost planar (torsion angle N2-C5-C6-C7–5.4°) and that S1 at the thienyl moiety is anti-periplanar to N2 (torsion angle N2-C5-C6-S1 176.01); no disorder effect was observed for the thienyl ring.
American Psychological Association (APA)
Flores, Alex F. C.& Kuhn, Bruna P.& Flores, Darlene C.& Pereira, Mariano A.& Balliano, Tatiane L.& da Silva, Givanildo S.. 2018. Synthesis, Structure, and Cyclocondensation of the 4,4,4-Trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)-1-butanone with Hydroxylamine and Hydrazine. Journal of Spectroscopy،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202639
Modern Language Association (MLA)
Flores, Alex F. C.…[et al.]. Synthesis, Structure, and Cyclocondensation of the 4,4,4-Trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)-1-butanone with Hydroxylamine and Hydrazine. Journal of Spectroscopy No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1202639
American Medical Association (AMA)
Flores, Alex F. C.& Kuhn, Bruna P.& Flores, Darlene C.& Pereira, Mariano A.& Balliano, Tatiane L.& da Silva, Givanildo S.. Synthesis, Structure, and Cyclocondensation of the 4,4,4-Trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)-1-butanone with Hydroxylamine and Hydrazine. Journal of Spectroscopy. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202639