Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities
Joint Authors
Wang, Guan
Liu, Wei
Wang, Xiaohui
O’Connor, Margaret
Han, Fang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society.
Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time.
The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage.
Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments.
In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.
American Psychological Association (APA)
Liu, Wei& Wang, Xiaohui& O’Connor, Margaret& Wang, Guan& Han, Fang. 2020. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202642
Modern Language Association (MLA)
Liu, Wei…[et al.]. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1202642
American Medical Association (AMA)
Liu, Wei& Wang, Xiaohui& O’Connor, Margaret& Wang, Guan& Han, Fang. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202642