![](/images/graphics-bg.png)
Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis
Joint Authors
Peña-Ortega, Fernando
Mondragón-Rodríguez, Siddhartha
Salgado-Burgos, Humberto
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
For more than five decades, the field of Alzheimer’s disease (AD) has focused on two main hypotheses positing amyloid-beta (Aβ) and Tau phosphorylation (pTau) as key pathogenic mediators.
In line with these canonical hypotheses, several groups around the world have shown that the synaptotoxicity in AD depends mainly on the increase in pTau levels.
Confronting this leading hypothesis, a few years ago, we reported that the increase in phosphorylation levels of dendritic Tau, at its microtubule domain (MD), acts as a neuroprotective mechanism that prevents N-methyl-D-aspartate receptor (NMDAr) overexcitation, which allowed us to propose that Tau protein phosphorylated near MD sites is involved in neuroprotection, rather than in neurodegeneration.
Further supporting this alternative role of pTau, we have recently shown that early increases in pTau close to MD sites prevent hippocampal circuit overexcitation in a transgenic AD mouse model.
Here, we will synthesize this new evidence that confronts the leading Tau-based AD hypothesis and discuss the role of pTau modulating neural circuits and network connectivity.
Additionally, we will briefly address the role of brain circuit alterations as a potential biomarker for detecting the prodromal AD stage.
American Psychological Association (APA)
Mondragón-Rodríguez, Siddhartha& Salgado-Burgos, Humberto& Peña-Ortega, Fernando. 2020. Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202655
Modern Language Association (MLA)
Mondragón-Rodríguez, Siddhartha…[et al.]. Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1202655
American Medical Association (AMA)
Mondragón-Rodríguez, Siddhartha& Salgado-Burgos, Humberto& Peña-Ortega, Fernando. Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202655