![](/images/graphics-bg.png)
The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons
Joint Authors
Zhou, Lei
Shen, Na
Lai, Bin
Li, Shufeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Cochlear implant-based electrical stimulation may be an important reason to induce the residual hearing loss after cochlear implantation.
In our previous study, we found that charge-balanced biphasic electrical stimulation inhibited the neurite growth of spiral ganglion neurons (SGNs) and decreased Schwann cell density in vitro.
In this study, we want to know whether cochlear implant-based electrical stimulation can induce the change of electrical activity in cultured SGNs.
Methods.
Spiral ganglion neuron electrical stimulation in vitro model is established using the devices delivering cochlear implant-based electrical stimulation.
After 48 h treatment by 50 μA or 100 μA electrical stimulation, the action potential (AP) and voltage depended calcium current (ICa) of SGNs are recorded using whole-cell electrophysiological method.
Results.
The results show that the ICa of SGNs is decreased significantly in 50 μA and 100 μA electrical stimulation groups.
The reversal potential of ICa is nearly +80 mV in control SGN, but the reversal potential decreases to +50 mV in 50 μA and 100 μA electrical stimulation groups.
Interestingly, the AP amplitude, the AP latency, and the AP duration of SGNs have no statistically significant differences in all three groups.
Conclusion.
Our study suggests cochlear implant-based electrical stimulation only significantly inhibit the ICa of cultured SGNs but has no effect on the firing of AP, and the relation of ICa inhibition and SGN damage induced by electrical stimulation and its mechanism needs to be further studied.
American Psychological Association (APA)
Shen, Na& Zhou, Lei& Lai, Bin& Li, Shufeng. 2020. The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons. Neural Plasticity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1202659
Modern Language Association (MLA)
Shen, Na…[et al.]. The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons. Neural Plasticity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1202659
American Medical Association (AMA)
Shen, Na& Zhou, Lei& Lai, Bin& Li, Shufeng. The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1202659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202659