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Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway
Joint Authors
Ueda-Nakamura, Tânia
Truiti, Maria da Conceição Torrado
Nakamura, Celso Vataru
Auzely, Rachel
Oliveira, Mariana M.
Daré, Regina G.
Silva, Sueli de Oliveira
Ratti, Bianca Altrão
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging.
Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage.
The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB.
DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay.
DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H2O2) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels.
Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression.
Furthermore, DHCA reduced the phosphorylation of MAPK p38.
These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.
American Psychological Association (APA)
Oliveira, Mariana M.& Ratti, Bianca Altrão& Daré, Regina G.& Silva, Sueli de Oliveira& Truiti, Maria da Conceição Torrado& Ueda-Nakamura, Tânia…[et al.]. 2019. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202662
Modern Language Association (MLA)
Oliveira, Mariana M.…[et al.]. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202662
American Medical Association (AMA)
Oliveira, Mariana M.& Ratti, Bianca Altrão& Daré, Regina G.& Silva, Sueli de Oliveira& Truiti, Maria da Conceição Torrado& Ueda-Nakamura, Tânia…[et al.]. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202662