Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain
Joint Authors
Luo, Ceng
Sun, Zhi-Chuan
Ma, Sui-Bin
Chu, Wen-Guang
Jia, Dong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients.
Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive.
It is assumed that abnormal increase of calcium levels in the cells is a key determinant in the transition from acute to chronic pain.
Exploring molecular players mediating Ca2+ entry into cells and molecular mechanisms underlying activity-dependent changes in Ca2+ signaling in the somatosensory pain pathway is therefore helpful towards understanding the development of chronic, pathological pain.
Canonical transient receptor potential (TRPC) channels form a subfamily of nonselective cation channels, which permit the permeability of Ca2+ and Na+ into the cells.
Initiation of Ca2+ entry pathways by these channels triggers the development of many physiological and pathological functions.
In this review, we will focus on the functional implication of TRPC channels in nociception with the elucidation of their role in the detection of external stimuli and nociceptive hypersensitivity.
American Psychological Association (APA)
Sun, Zhi-Chuan& Ma, Sui-Bin& Chu, Wen-Guang& Jia, Dong& Luo, Ceng. 2020. Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202674
Modern Language Association (MLA)
Sun, Zhi-Chuan…[et al.]. Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1202674
American Medical Association (AMA)
Sun, Zhi-Chuan& Ma, Sui-Bin& Chu, Wen-Guang& Jia, Dong& Luo, Ceng. Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202674