Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus
Joint Authors
Wang, Hui
Shi, Haibo
Nan, Wenya
Zhang, Jiajia
Yin, Shankai
Feng, Yanmei
Zhang, Zhen
Huang, Shujian
Zhou, Huiqun
Wang, Dan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study was aimed at delineating and comparing differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus (LFT and HFT, respectively) using high-density electroencephalography (EEG).
This study enrolled 3217 patients with subjective tinnitus who were divided into LFT (frequency<4000 Hz) and HFT (≥4000 Hz) groups.
Data regarding medical history, Tinnitus Handicap Inventory, tinnitus matching, and hearing threshold were collected from all patients.
Twenty tinnitus patients and 20 volunteers were subjected to 256-channel EEG, and neurophysiological differences were evaluated using standardized low-resolution brain electromagnetic tomography (sLORETA) source-localized EEG recordings.
Significant differences in sex (p<0.001), age (p=0.022), laterality (p<0.001), intensity (p<0.001), tinnitus type (p<0.001), persistent tinnitus (p=0.04), average threshold (p<0.001), and hearing loss (p=0.028) were observed between LFT and HFT groups.
The tinnitus pitch only appeared to be correlated with the threshold of the worst hearing loss in the HFT group.
Compared with the controls, the LFT group exhibited increased gamma power (p<0.05), predominantly in the posterior cingulate cortex (PCC, BA31), whereas the HFT group had significantly decreased alpha1 power (p<0.05) in the angular gyrus (BA39) and auditory association cortex (BA22).
Higher gamma linear connectivity between right BA39 and right BA41 was observed in the HFT group relative to controls (t=3.637, p=0.027).
Significant changes associated with increased gamma in the LFT group and decreased alpha1 in the HFT group indicate that tinnitus pitch is crucial for matching between the tinnitus and control groups.
Differences of band frequency energy in brain activity levels may contribute to the clinical characteristics and internal tinnitus “spectrum” differences.
American Psychological Association (APA)
Zhang, Jiajia& Zhang, Zhen& Huang, Shujian& Zhou, Huiqun& Feng, Yanmei& Shi, Haibo…[et al.]. 2020. Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus. Neural Plasticity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202701
Modern Language Association (MLA)
Zhang, Jiajia…[et al.]. Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus. Neural Plasticity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1202701
American Medical Association (AMA)
Zhang, Jiajia& Zhang, Zhen& Huang, Shujian& Zhou, Huiqun& Feng, Yanmei& Shi, Haibo…[et al.]. Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202701