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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro
Joint Authors
Labrador-Rached, Claudia J.
Browning, Rebecca T.
Braydich-Stolle, Laura K.
Comfort, Kristen K.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Due to their distinctive physicochemical properties, platinum nanoparticles (PtNPs) have emerged as a material of interest for a number of biomedical therapeutics.
However, in some instances NP exposure has been correlated to health and safety concerns, including cytotoxicity, activation of cellular stress, and modification to normal cell functionality.
As PtNPs have induced differential cellular responses in vitro, the goal of this study was to further characterize the behavior and toxicological potential of PtNPs within a HepG2 liver model.
This study identified that a high PtNP dosage induced HepG2 cytotoxicity.
However, lower, subtoxic PtNP concentrations were able to elicit multiple stress responses, secretion of proinflammatory cytokines, and modulation of insulin-like growth factor-1 dependent signal transduction.
Taken together, this work suggests that PtNPs would not be overtly toxic for acute exposures, but sustained cellular interactions might produce long term health consequences.
American Psychological Association (APA)
Labrador-Rached, Claudia J.& Browning, Rebecca T.& Braydich-Stolle, Laura K.& Comfort, Kristen K.. 2018. Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202709
Modern Language Association (MLA)
Labrador-Rached, Claudia J.…[et al.]. Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro. Journal of Toxicology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1202709
American Medical Association (AMA)
Labrador-Rached, Claudia J.& Browning, Rebecca T.& Braydich-Stolle, Laura K.& Comfort, Kristen K.. Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202709