Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder
Joint Authors
Guo, Yongxin
Cui, Dong
Chen, Haoran
Cao, Weifang
Jiao, Qing
Gao, Weijia
Qiu, Jianfeng
Su, Linyan
Lu, Guangming
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Accumulating studies demonstrate emotional and cognitive dysregulation in the euthymic period of pediatric bipolar disorder (PBD).
However, the relative contribution of functional integration in human brain to disturbed emotion and cognitive function in the euthymic PBD patients remains unclear.
In this study, 16 euthymic PBD patients and 16 healthy controls underwent resting-state functional magnetic resonance imaging.
A data-driven functional connectivity analysis was used to investigate functional connectivity changes of the euthymic PBD.
Compared with healthy controls, the euthymic PBD exhibited greater global functional connectivity density in the left anterior insula and lower global functional connectivity density in the right temporoparietal junction, the left angular gyrus, and the bilateral occipital lobule.
A distant functional connectivity analysis demonstrated altered integration within the salience and default mode networks in euthymic PBD.
Correlation analysis found that altered functional connectivity of the salience network was related to the reduced performance in the backward digit span test, and altered functional connectivity of the default mode network was related to the Young Mania Rating Scale in euthymic PBD patients.
Our findings indicated that disturbed functional integration in salience and default mode networks might shed light on the physiopathology associated with emotional and cognitive dysregulation in PBD.
American Psychological Association (APA)
Cao, Weifang& Chen, Haoran& Jiao, Qing& Cui, Dong& Guo, Yongxin& Gao, Weijia…[et al.]. 2020. Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder. Neural Plasticity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1202712
Modern Language Association (MLA)
Cao, Weifang…[et al.]. Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder. Neural Plasticity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1202712
American Medical Association (AMA)
Cao, Weifang& Chen, Haoran& Jiao, Qing& Cui, Dong& Guo, Yongxin& Gao, Weijia…[et al.]. Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1202712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202712