Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Joint Authors

Pessoa, Claudia
Pêgas Henriques, João Antonio
Guecheva, Temenouga Nikolova
Vargas, José Eduardo
Puga, Renato
Trindade, Cristiano
Juchem, André Luiz Mendes
de Oliveira, Iuri M.
dos Santos Silveira, Priscila

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-10-24

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology

Abstract EN

Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established.

In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications.

Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties.

The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties.

In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways.

This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment.

Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.

American Psychological Association (APA)

Trindade, Cristiano& Juchem, André Luiz Mendes& Guecheva, Temenouga Nikolova& de Oliveira, Iuri M.& dos Santos Silveira, Priscila& Vargas, José Eduardo…[et al.]. 2019. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202724

Modern Language Association (MLA)

Trindade, Cristiano…[et al.]. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202724

American Medical Association (AMA)

Trindade, Cristiano& Juchem, André Luiz Mendes& Guecheva, Temenouga Nikolova& de Oliveira, Iuri M.& dos Santos Silveira, Priscila& Vargas, José Eduardo…[et al.]. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202724

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1202724