Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties
Joint Authors
Pessoa, Claudia
Pêgas Henriques, João Antonio
Guecheva, Temenouga Nikolova
Vargas, José Eduardo
Puga, Renato
Trindade, Cristiano
Juchem, André Luiz Mendes
de Oliveira, Iuri M.
dos Santos Silveira, Priscila
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established.
In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications.
Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties.
The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties.
In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways.
This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment.
Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.
American Psychological Association (APA)
Trindade, Cristiano& Juchem, André Luiz Mendes& Guecheva, Temenouga Nikolova& de Oliveira, Iuri M.& dos Santos Silveira, Priscila& Vargas, José Eduardo…[et al.]. 2019. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202724
Modern Language Association (MLA)
Trindade, Cristiano…[et al.]. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202724
American Medical Association (AMA)
Trindade, Cristiano& Juchem, André Luiz Mendes& Guecheva, Temenouga Nikolova& de Oliveira, Iuri M.& dos Santos Silveira, Priscila& Vargas, José Eduardo…[et al.]. Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202724