Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1
Joint Authors
Louisa, Melva
Sundari, Nanik
Wardhani, Bantari W.
Soetikno, Vivian
Tjandrawinata, Raymond R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phaleria macrocarpa is one of the Indonesian herbal plants which has been shown to have a hepatoprotective effect.
This study was conducted to evaluate the protective effect of water extract of mahkota dewa (Phaleria macrocarpa) in liver fibrosis and to elucidate its mechanism of action.
Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) for 8 weeks to induce liver fibrosis.
Rats were randomly divided into 6 groups (n=5), i.e., control group, CCl4 group, CCl4 + NAC group, CCl4 + various doses of water extract of Phaleria macrocarpa (50, 100, and 150 mg/kg body weight).
Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), liver histopathology, malondialdehyde (MDA), ratio GSH/GSSG, Tumor Necrosis Factor- (TNF-) α, and Transforming Growth Factor- (TGF-) β1 were analyzed.
This study demonstrated that water extract of Phaleria macrocarpa and NAC significantly protected CCl4-induced liver injury as demonstrated by reduced AST, ALT, ALP, and fibrosis percentage compared with the CCl4-only group.
In addition, water extract of Phaleria macrocarpa and NAC significantly reduced the levels of MDA, TNF-α, and TGF-β1 as well as increasing the ratio of GSH/GSSG.
Water extract of Phaleria macrocarpa prevents CCl4-induced fibrosis in rats.
The prevention of liver fibrosis was at least in part through its antioxidant and anti-inflammatory activities and through its capacity to inhibit hepatic stellate cells (HSC) activation by reducing fibrogenic cytokine TGF-β1.
American Psychological Association (APA)
Sundari, Nanik& Soetikno, Vivian& Louisa, Melva& Wardhani, Bantari W.& Tjandrawinata, Raymond R.. 2018. Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1202734
Modern Language Association (MLA)
Sundari, Nanik…[et al.]. Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1. Journal of Toxicology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1202734
American Medical Association (AMA)
Sundari, Nanik& Soetikno, Vivian& Louisa, Melva& Wardhani, Bantari W.& Tjandrawinata, Raymond R.. Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1202734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202734