Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder
Joint Authors
Sueyoshi, Noriyuki
Kameshita, Isamu
Katayama, Syouichi
Inazu, Tetsuya
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cyclin-dependent kinase-like 5 (CDKL5, also known as STK9) is a serine/threonine protein kinase originally identified in 1998 during a transcriptional mapping project of the human X chromosome.
Thereafter, a mutation in CDKL5 was reported in individuals with the atypical Rett syndrome, a neurodevelopmental disorder, suggesting that CDKL5 plays an important regulatory role in neuronal function.
The disease associated with CDKL5 mutation has recently been recognised as CDKL5 deficiency disorder (CDD) and has been distinguished from the Rett syndrome owing to its symptomatic manifestation.
Because CDKL5 mutations identified in patients with CDD cause enzymatic loss of function, CDKL5 catalytic activity is likely strongly associated with the disease.
Consequently, the exploration of CDKL5 substrate characteristics and regulatory mechanisms of its catalytic activity are important for identifying therapeutic target molecules and developing new treatment.
In this review, we summarise recent findings on the phosphorylation of CDKL5 substrates and the mechanisms of CDKL5 phosphorylation and dephosphorylation.
We also discuss the relationship between changes in the phosphorylation signalling pathways and the Cdkl5 knockout mouse phenotype and consider future prospects for the treatment of mental and neurological disease associated with CDKL5 mutations.
American Psychological Association (APA)
Katayama, Syouichi& Sueyoshi, Noriyuki& Inazu, Tetsuya& Kameshita, Isamu. 2020. Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder. Neural Plasticity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1202750
Modern Language Association (MLA)
Katayama, Syouichi…[et al.]. Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder. Neural Plasticity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1202750
American Medical Association (AMA)
Katayama, Syouichi& Sueyoshi, Noriyuki& Inazu, Tetsuya& Kameshita, Isamu. Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1202750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202750