Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells
Joint Authors
Raji, J. I.
Onwuamah, C. K.
Odeigah, P. G. C.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries.
Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell.
Here, the cytogenotoxicity of dihydroartemisinin-piperaquine phosphate (DHAP), a coformulation for artemisinin-based combination therapy, was evaluated using Allium cepa model.
The toxicity on the mitotic index varies with the duration of exposure and dose tested.
Chromosome aberrations observed include chromosome fragments, chromosome bridges, binucleated cells, and micronucleated cells.
This study showed that DHAP can depress mitosis and induce chromosome abnormalities.
Their accumulation in cells may be inhibitory to cell division and growth.
This calls for caution in the administration of artemisinin combination therapy for the treatment of malaria ailment.
Wide spacing of dosage is therefore suggested in order to avoid the risk of genetic damage.
American Psychological Association (APA)
Raji, J. I.& Onwuamah, C. K.& Odeigah, P. G. C.. 2018. Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1202765
Modern Language Association (MLA)
Raji, J. I.…[et al.]. Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells. Journal of Toxicology No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1202765
American Medical Association (AMA)
Raji, J. I.& Onwuamah, C. K.& Odeigah, P. G. C.. Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1202765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202765