![](/images/graphics-bg.png)
Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer’s Disease: A Graph-Based Resting-State fMRI Study
Joint Authors
Ullah, Farman
Rehman, Zia Ur
Talpur, Hira Sajjad
Hosseini, Seyed Mahdi
Liang, Aixin
Hua, Guohua
The Alzheimer's Disease Neuroimaging Initiative, Wenliang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
AD is a common chronic progressive neurodegenerative disorder.
However, the understanding of the dynamic longitudinal change of the brain in the progression of AD is still rough and sometimes conflicting.
This paper analyzed the brain networks of healthy people and patients at different stages (EMCI, LMCI, and AD).
The results showed that in global network properties, most differences only existed between healthy people and patients, and few were discovered between patients at different stages.
However, nearly all subnetwork properties showed significant differences between patients at different stages.
Moreover, the most interesting result was that we found two different functional evolving patterns of cortical networks in progression of AD, named ‘temperature inversion’ and “monotonous decline,” but not the same monotonous decline trend as the external functional assessment observed in the course of disease progression.
We suppose that those subnetworks, showing the same functional evolving pattern in AD progression, may have something the same in work mechanism in nature.
And the subnetworks with ‘temperature inversion’ evolving pattern may play a special role in the development of AD.
American Psychological Association (APA)
Ullah, Farman& Hosseini, Seyed Mahdi& Rehman, Zia Ur& Hua, Guohua& Liang, Aixin& Talpur, Hira Sajjad…[et al.]. 2020. Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer’s Disease: A Graph-Based Resting-State fMRI Study. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202766
Modern Language Association (MLA)
Ullah, Farman…[et al.]. Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer’s Disease: A Graph-Based Resting-State fMRI Study. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1202766
American Medical Association (AMA)
Ullah, Farman& Hosseini, Seyed Mahdi& Rehman, Zia Ur& Hua, Guohua& Liang, Aixin& Talpur, Hira Sajjad…[et al.]. Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer’s Disease: A Graph-Based Resting-State fMRI Study. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202766