Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production
Joint Authors
Chen, Kai
Guan, Yiqing
Ma, Yunci
Quan, Dongling
Zhang, Jingru
Wu, Shaoyu
Liu, Xin
Lv, Lin
Zhang, Guohua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Current therapeutic approaches have a limited effect on cardiac remodeling, which is characteristic of cardiac fibrosis and myocardial hypertrophy.
In this study, we examined whether Danshenol A (DA), an active ingredient extracted from the traditional Chinese medicine Radix Salviae, can attenuate cardiac remodeling and clarified the underlying mechanisms.
Using the spontaneously hypertensive rat (SHR) as a cardiac remodeling model, DA ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function.
Bioinformatics analysis revealed that DA might attenuate cardiac remodeling through modulating mitochondrial dysfunction and reactive oxygen species.
DA repaired the structure/function of the mitochondria, alleviated oxidative stress in the myocardium, and restored apoptosis of cardiomyocytes induced by angiotensin II.
Besides, DA inhibited mitochondrial redox signaling pathways in both the myocardium and cardiomyocytes.
Thus, our study suggested that DA attenuates cardiac remodeling induced by hypertension through modulating mitochondrial dysfunction and reactive oxygen species.
American Psychological Association (APA)
Chen, Kai& Guan, Yiqing& Ma, Yunci& Quan, Dongling& Zhang, Jingru& Wu, Shaoyu…[et al.]. 2019. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1202782
Modern Language Association (MLA)
Chen, Kai…[et al.]. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1202782
American Medical Association (AMA)
Chen, Kai& Guan, Yiqing& Ma, Yunci& Quan, Dongling& Zhang, Jingru& Wu, Shaoyu…[et al.]. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1202782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202782