EEG Correlates of Central Origin of Cancer-Related Fatigue
Joint Authors
Siemionow, Vlodek
Ranganathan, Vinoth K.
Allexandre, Didier
Seyidova-Khoshknabi, Dilara
Davis, Mellar P.
Walsh, Declan
Yue, Guang H.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood.
EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribution to early fatigue during SC in CRF.
Advanced cancer patients and matched healthy controls performed an elbow flexor SC until task failure while undergoing neuromuscular testing and EEG recording.
EEG power changes over left and right sensorimotor cortices were analyzed and correlated with brief fatigue inventory (BFI) score and evoked muscle force, a measure of central fatigue.
Brain electrical activity changes during the SC differed in CRF from healthy subjects mainly in the theta (4-8 Hz) and beta (12-30 Hz) bands in the contralateral (to the fatigued limb) hemisphere; changes were correlated with the evoked force.
Also, the gamma band (30-50 Hz) power decrease during the SC did not return to baseline after 2 min of rest in CRF, an effect correlated with BFI score.
In conclusion, altered brain electrical activity during a fatigue task in patients is associated with central fatigue during SC or fatigue symptoms, suggesting its potential contribution to CRF during motor performance.
This information should guide the development and use of rehabilitative interventions that target the central nervous system to maximize function recovery.
American Psychological Association (APA)
Allexandre, Didier& Seyidova-Khoshknabi, Dilara& Davis, Mellar P.& Ranganathan, Vinoth K.& Siemionow, Vlodek& Walsh, Declan…[et al.]. 2020. EEG Correlates of Central Origin of Cancer-Related Fatigue. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202783
Modern Language Association (MLA)
Allexandre, Didier…[et al.]. EEG Correlates of Central Origin of Cancer-Related Fatigue. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1202783
American Medical Association (AMA)
Allexandre, Didier& Seyidova-Khoshknabi, Dilara& Davis, Mellar P.& Ranganathan, Vinoth K.& Siemionow, Vlodek& Walsh, Declan…[et al.]. EEG Correlates of Central Origin of Cancer-Related Fatigue. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202783