Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application
Joint Authors
Havas, Fabien
Krispin, Shlomo
von Oppen-Bezalel, Liki
Melendez-Martinez, Antonio J.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin.
Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern.
However, since the interest in these compounds in the context of many applications is expanding, it is important to conduct studies aimed at assessing their safety.
We present here results of in vitro cytotoxicity and genotoxicity studies, revealing no significant cytotoxic or genotoxic potential and of short- and long-term human in vivo skin compatibility studies with phytoene- and phytofluene-rich tomato and Dunaliella salina alga extracts, showing a lack of irritancy or sensitization reactions.
These results support the safe use of phytoene- and phytofluene-rich products in human topical applications.
American Psychological Association (APA)
Havas, Fabien& Krispin, Shlomo& Melendez-Martinez, Antonio J.& von Oppen-Bezalel, Liki. 2018. Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202787
Modern Language Association (MLA)
Havas, Fabien…[et al.]. Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application. Journal of Toxicology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1202787
American Medical Association (AMA)
Havas, Fabien& Krispin, Shlomo& Melendez-Martinez, Antonio J.& von Oppen-Bezalel, Liki. Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1202787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202787