Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress
Joint Authors
Li, Jie
Xu, Xiaotian
Cai, Xiaoying
Weng, Yinlun
Wang, Yiping
Shen, Qingyu
Shi, Xiaolei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxidative stress plays an important role in various neurological disorders.
Milk fat globule-epidermal growth factor-factor 8 (MFG-E8) is a regulatory protein for microglia.
However, its involvement in microglial oxidative stress has not been established.
In this study, we observed microglial oxidative stress in response to lipopolysaccharide (LPS) both in vitro and in vivo.
LPS induced significant elevation of TNF-α, IL-6, MDA, and ROS and reduction of GSH and SOD in the mouse brains and primary microglia, which were reversed by MFG-E8 pretreatment.
MFG-E8 induced the expression of Nrf-2 and HO-1 that was reduced by LPS incubation.
Moreover, LPS-increased Keap-1 expression was reversed by MFG-E8.
But the above tendencies were not seen when MFG-E8 was applied alone.
The current study established the involvement of MFG-E8 in antioxidant effects during neuroinflammation.
It may achieve the effects through the regulation of Keap-1/Nrf-2/HO-1 pathways.
American Psychological Association (APA)
Li, Jie& Xu, Xiaotian& Cai, Xiaoying& Weng, Yinlun& Wang, Yiping& Shen, Qingyu…[et al.]. 2019. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202800
Modern Language Association (MLA)
Li, Jie…[et al.]. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1202800
American Medical Association (AMA)
Li, Jie& Xu, Xiaotian& Cai, Xiaoying& Weng, Yinlun& Wang, Yiping& Shen, Qingyu…[et al.]. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202800