Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss
Joint Authors
Wei, Mei
Wang, Wei
Liu, Yao
Mao, Xiang
Chen, Tai Sheng
Lin, Peng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the auditory system, ribbon synapses are vesicle-associated structures located between inner hair cells (IHCs) and spiral ganglion neurons that are implicated in the modulation of trafficking and fusion of synaptic vesicles at the presynaptic terminals.
Synapse loss may result in hearing loss and difficulties with understanding speech in a noisy environment.
This phenomenon happens without permanent hearing loss; that is, the cochlear synaptopathy is “hidden.” Recent studies have reported that synapse loss might be critical in the pathogenesis of hidden hearing loss.
A better understanding of the molecular mechanisms of the formation, structure, regeneration, and protection of ribbon synapses will assist in the design of potential therapeutic strategies.
In this review, we describe and summarize the following aspects of ribbon synapses: (1) functional and structural features, (2) potential mechanisms of damage, (3) therapeutic research on protecting the synapses, and (4) the role of synaptic regeneration in auditory neuropathy and the current options for synapse rehabilitation.
American Psychological Association (APA)
Wei, Mei& Wang, Wei& Liu, Yao& Mao, Xiang& Chen, Tai Sheng& Lin, Peng. 2020. Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202801
Modern Language Association (MLA)
Wei, Mei…[et al.]. Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1202801
American Medical Association (AMA)
Wei, Mei& Wang, Wei& Liu, Yao& Mao, Xiang& Chen, Tai Sheng& Lin, Peng. Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202801