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Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity
Joint Authors
Qin, Zongshi
Shen, Jiangang
Zheng, Yu
Zhang, Zhang-Jin
Tsoi, Bun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Poststroke cognitive impairment (PSCI) is a severe sequela of stroke.
There are no effective therapeutic options for it.
In this study, we evaluated whether electroacupuncture (EA) on the trigeminal nerve-innervated acupoints could alleviate PSCI and identified the mechanisms in an animal model.
The male Sprague-Dawley rat middle cerebral artery occlusion (MCAO) model was used in our study.
EA was conducted on the two scalp acupoints, EX-HN3 (Yintang) and GV20 (Baihui), innervated by the trigeminal nerve, for 14 sessions, daily.
Morris water maze and novel object recognition were used to evaluate the animal’s cognitive performance.
Neuroprotection and synaptic plasticity biomarkers were analyzed in brain tissues.
Ischemia-reperfusion (I/R) injury significantly impaired spatial and cognition memory, while EA obviously reversed cognitive deterioration to the control level in the two cognitive paradigms.
Moreover, EA reversed the I/R injury-induced decrease of brain-derived neurotrophic factor, tyrosine kinase B, N-methyl-D-aspartic acid receptor 1, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, γ-aminobutyric acid type A receptors, Ca2+/calmodulin-dependent protein kinase II, neuronal nuclei, and postsynaptic density protein 95 expression in the prefrontal cortex and hippocampus.
These results suggest that EA on the trigeminal nerve-innervated acupoints is an effective therapy for PSCI, in association with mediating neuroprotection and synaptic plasticity in related brain regions in the MCAO rat model.
American Psychological Association (APA)
Zheng, Yu& Qin, Zongshi& Tsoi, Bun& Shen, Jiangang& Zhang, Zhang-Jin. 2020. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202804
Modern Language Association (MLA)
Zheng, Yu…[et al.]. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1202804
American Medical Association (AMA)
Zheng, Yu& Qin, Zongshi& Tsoi, Bun& Shen, Jiangang& Zhang, Zhang-Jin. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202804