Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

Joint Authors

Qin, Zongshi
Shen, Jiangang
Zheng, Yu
Zhang, Zhang-Jin
Tsoi, Bun

Source

Neural Plasticity

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-09-07

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology
Medicine

Abstract EN

Poststroke cognitive impairment (PSCI) is a severe sequela of stroke.

There are no effective therapeutic options for it.

In this study, we evaluated whether electroacupuncture (EA) on the trigeminal nerve-innervated acupoints could alleviate PSCI and identified the mechanisms in an animal model.

The male Sprague-Dawley rat middle cerebral artery occlusion (MCAO) model was used in our study.

EA was conducted on the two scalp acupoints, EX-HN3 (Yintang) and GV20 (Baihui), innervated by the trigeminal nerve, for 14 sessions, daily.

Morris water maze and novel object recognition were used to evaluate the animal’s cognitive performance.

Neuroprotection and synaptic plasticity biomarkers were analyzed in brain tissues.

Ischemia-reperfusion (I/R) injury significantly impaired spatial and cognition memory, while EA obviously reversed cognitive deterioration to the control level in the two cognitive paradigms.

Moreover, EA reversed the I/R injury-induced decrease of brain-derived neurotrophic factor, tyrosine kinase B, N-methyl-D-aspartic acid receptor 1, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, γ-aminobutyric acid type A receptors, Ca2+/calmodulin-dependent protein kinase II, neuronal nuclei, and postsynaptic density protein 95 expression in the prefrontal cortex and hippocampus.

These results suggest that EA on the trigeminal nerve-innervated acupoints is an effective therapy for PSCI, in association with mediating neuroprotection and synaptic plasticity in related brain regions in the MCAO rat model.

American Psychological Association (APA)

Zheng, Yu& Qin, Zongshi& Tsoi, Bun& Shen, Jiangang& Zhang, Zhang-Jin. 2020. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202804

Modern Language Association (MLA)

Zheng, Yu…[et al.]. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1202804

American Medical Association (AMA)

Zheng, Yu& Qin, Zongshi& Tsoi, Bun& Shen, Jiangang& Zhang, Zhang-Jin. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202804

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1202804