An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
Joint Authors
Damarla, Sreenivasa Rao
Komma, Rajesh
Bhatnagar, Upendra
Rajesh, Navin
Mulla, Sadik Mohmad Abdulhamid
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-16
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
A battery of toxicological studies was conducted in accordance with international guidelines to investigate the genotoxicity and repeated-dose oral toxicity in rats of synthetic curcumin (VEAMIN 99, >99% purity).
There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas an in vitro mammalian chromosomal aberration test was positive for induction of chromosomal aberrations which is in line with results reported for natural curcumin.
There was no evidence of genotoxicity in an in vivo mammalian micronucleus test.
Synthetic curcumin did not cause mortality or toxic effects in a 90-day repeated-dose oral toxicity study at daily doses of 250, 500, or 1000 mg/kg body weight (bw)/day (administered by gavage in a split dose).
The no observed adverse effect level (NOAEL) determined from the 90-day study was 1000 mg/kg bw/day for both male and female Wistar rats.
American Psychological Association (APA)
Damarla, Sreenivasa Rao& Komma, Rajesh& Bhatnagar, Upendra& Rajesh, Navin& Mulla, Sadik Mohmad Abdulhamid. 2018. An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1202811
Modern Language Association (MLA)
Damarla, Sreenivasa Rao…[et al.]. An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin. Journal of Toxicology No. 2018 (2018), pp.1-27.
https://search.emarefa.net/detail/BIM-1202811
American Medical Association (AMA)
Damarla, Sreenivasa Rao& Komma, Rajesh& Bhatnagar, Upendra& Rajesh, Navin& Mulla, Sadik Mohmad Abdulhamid. An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1202811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202811