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An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp
Joint Authors
Clewell, Amy
Glávits, Róbert
Endres, John R.
Marx, Tennille
Reddeman, Robin A.
Hirka, Gábor
Vértesi, Adél
Béres, Erzsébet
Szakonyiné, Ilona Pasics
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-07
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
A battery of toxicological studies was conducted on a supercritical CO2 extract of the aerial parts of the Cannabis sativa plant, containing approximately 25% cannabinoids.
No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study.
A 14-day repeated oral dose-range finding study conducted in Wistar rats at 1000, 2000, and 4000 mg/kg bw/day resulted in effects where a NOAEL could not be concluded.
Based on those results, a 90-day repeated dose oral toxicity study was performed in rats using doses of 100, 360, and 720 mg/kg bw/day, followed by a 28-day recovery period for two satellite groups.
Significant decreases in body weight, body weight gain, and differences in various organ weights compared to controls were observed.
At the end of the recovery period, many of the findings were trending toward normal; thus, the changes appeared to be reversible.
The NOAEL for the hemp extract in Hsd.Han Wistar rats was considered to be 100 mg/kg bw/day for males and 360 mg/kg bw/day for females.
American Psychological Association (APA)
Marx, Tennille& Reddeman, Robin A.& Clewell, Amy& Endres, John R.& Béres, Erzsébet& Vértesi, Adél…[et al.]. 2018. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-26.
https://search.emarefa.net/detail/BIM-1202852
Modern Language Association (MLA)
Marx, Tennille…[et al.]. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. Journal of Toxicology No. 2018 (2018), pp.1-26.
https://search.emarefa.net/detail/BIM-1202852
American Medical Association (AMA)
Marx, Tennille& Reddeman, Robin A.& Clewell, Amy& Endres, John R.& Béres, Erzsébet& Vértesi, Adél…[et al.]. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-26.
https://search.emarefa.net/detail/BIM-1202852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202852