![](/images/graphics-bg.png)
Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1M2 Polarization in Mice with Alzheimer’s Disease
Joint Authors
Huang, Sheng
Li, Le
Liu, Weilin
Liang, Shengxiang
Zhang, Jiayong
Li, Long
Tao, Jing
Wang, Zhifu
Chen, Lidian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD).
Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively.
Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD.
In this study, we demonstrated that electroacupuncture at the Shenting and Baihui acupoints for 16 weeks could improve learning and memory in the Morris water maze test and reduce amyloid β-protein in the parietal association cortex and entorhinal cortex in mice with mild and moderate AD.
Besides, electroacupuncture at the Shenting and Baihui acupoints not only suppressed M1 marker (iNOS/IL-1β) expression but also increased the M2 marker (CD206/Arg1) expression in those regions.
We propose that electroacupuncture at the Shenting and Baihui acupoints could regulate microglial polarization and decrease Aβ plaques to improve learning and memory in mild AD mice.
American Psychological Association (APA)
Li, Long& Li, Le& Zhang, Jiayong& Huang, Sheng& Liu, Weilin& Wang, Zhifu…[et al.]. 2020. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1M2 Polarization in Mice with Alzheimer’s Disease. Neural Plasticity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1202878
Modern Language Association (MLA)
Li, Long…[et al.]. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1M2 Polarization in Mice with Alzheimer’s Disease. Neural Plasticity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1202878
American Medical Association (AMA)
Li, Long& Li, Le& Zhang, Jiayong& Huang, Sheng& Liu, Weilin& Wang, Zhifu…[et al.]. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1M2 Polarization in Mice with Alzheimer’s Disease. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1202878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202878