Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death
Joint Authors
Sun, Qian-Yi
Zhou, Hong-Hao
Mao, Xiao-Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.
ALOX5 is the rate-limiting enzyme for the biosynthesis of leukotrienes, a family of proinflammatory lipid mediators derived from arachidonic acid.
ALOX5 also make great contributions to mediating lipid peroxidation.
In recent years, it has been discovered that ALOX5 plays a central role in cell death including apoptosis, pyroptosis, and ferroptosis, a newly discovered type of cell death.
According to the previous studies, ALOX5 can regulate cell death in two ways: one is inflammation and the other is lipid peroxidation.
Meanwhile, it has been shown that ALOX5 activity is regulated by several factors including protein phosphorylation, ALOX5-interactng protein, redox state, and metal ions such as iron and calcium.
In this review, we aim to summarize the knowledge on the emerging roles of ALOX5 protein phosphorylation in the regulation of cell death and inflammation in order to explore a potential target for human diseases.
American Psychological Association (APA)
Sun, Qian-Yi& Zhou, Hong-Hao& Mao, Xiao-Yuan. 2019. Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202912
Modern Language Association (MLA)
Sun, Qian-Yi…[et al.]. Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1202912
American Medical Association (AMA)
Sun, Qian-Yi& Zhou, Hong-Hao& Mao, Xiao-Yuan. Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202912