Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy
Joint Authors
Zheng, Xiaofei
Jin, Chenxi
Feng, Baoyi
Cheng, Zhenzhe
Zhao, Xingle
Sun, Zhuoer
Tao, Yong
Wu, Hao
Li, Xiang
Dong, Tingting
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited.
Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dysfunction is a dominant pathogenesis of AN.
Auditory pathway is a high energy consumption system, and SGNs required sufficient mitochondria.
Mitochondria are known treatment target of SNHL, but mitochondrion mechanism and pathology in SGNs are not valued.
Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN.
In this review, we summarized mitochondrial biological functions related to SGNs and discussed interaction between mitochondrial dysfunction and AN, as well as existing mitochondrion treatment for SNHL.
Pharmaceutical exploration to protect mitochondrion dysfunction is a feasible and effective therapeutics for AN.
American Psychological Association (APA)
Feng, Baoyi& Jin, Chenxi& Cheng, Zhenzhe& Zhao, Xingle& Sun, Zhuoer& Zheng, Xiaofei…[et al.]. 2020. Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy. Neural Plasticity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1202920
Modern Language Association (MLA)
Feng, Baoyi…[et al.]. Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy. Neural Plasticity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1202920
American Medical Association (AMA)
Feng, Baoyi& Jin, Chenxi& Cheng, Zhenzhe& Zhao, Xingle& Sun, Zhuoer& Zheng, Xiaofei…[et al.]. Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1202920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202920