Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1Nrf2ARE Signaling Pathway
Joint Authors
Narasimhan, Kishore Kumar S.
Jayakumar, Deepthy
Velusamy, Prema
Srinivasan, Ashokkumar
Mohan, Thangarajeswari
Ravi, Divya Bhavani
Uthamaraman, Saraswathi
Sathyamoorthy, Yogesh Kanna
Rajasekaran, Namakkal Soorappan
Periandavan, Kalaiselvi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Given the role of oxidative stress in PD pathogenesis and off-target side effects of currently available drugs, several natural phytochemicals seem to be promising in the management of PD.
Here, we tested the hypothesis that scopoletin, an active principle obtained from Morinda citrifolia (MC), efficiently quenches oxidative stress through DJ-1/Nrf2 signaling and ameliorates rotenone-induced PD.
Despite reducing oxidative stress, the administration of MC extract (MCE) has lessened protein aggregation as evident from decreased levels of nitrotyrosine and α-synuclein.
In vitro studies revealed that scopoletin lessened rotenone-induced apoptosis in SH-SY5Y cells through preventing oxidative injury.
Particularly, scopoletin markedly upregulated DJ-1, which then promoted the nuclear translocation of Nrf2 and transactivation of antioxidant genes.
Furthermore, we found that scopoletin prevents the nuclear exportation of Nrf2 by reducing the levels of Keap1 and thereby enhancing the neuronal defense system.
Overall, our findings suggest that scopoletin acts through DJ-1-mediated Nrf2 signaling to protect the brain from rotenone-induced oxidative stress and PD.
Thus, we postulate that scopoletin could be a potential drug to treat PD.
American Psychological Association (APA)
Narasimhan, Kishore Kumar S.& Jayakumar, Deepthy& Velusamy, Prema& Srinivasan, Ashokkumar& Mohan, Thangarajeswari& Ravi, Divya Bhavani…[et al.]. 2019. Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202924
Modern Language Association (MLA)
Narasimhan, Kishore Kumar S.…[et al.]. Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1202924
American Medical Association (AMA)
Narasimhan, Kishore Kumar S.& Jayakumar, Deepthy& Velusamy, Prema& Srinivasan, Ashokkumar& Mohan, Thangarajeswari& Ravi, Divya Bhavani…[et al.]. Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202924