Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite
Joint Authors
Lewin, Matthew R.
Bulfone, Tommaso C.
Samuel, Stephen P.
Bickler, Philip E.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD).
It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge.
Small molecule therapeutics (SMTs) have been proposed as potential prereferral treatments for snakebite to help address this gap.
Herein, we discuss the characteristics, potential uses, and development of SMTs as potential treatments for snakebite envenomation.
We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors with brief exploration of other potential drug targets on venom molecules.
American Psychological Association (APA)
Bulfone, Tommaso C.& Samuel, Stephen P.& Bickler, Philip E.& Lewin, Matthew R.. 2018. Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Journal of Tropical Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1202929
Modern Language Association (MLA)
Bulfone, Tommaso C.…[et al.]. Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Journal of Tropical Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1202929
American Medical Association (AMA)
Bulfone, Tommaso C.& Samuel, Stephen P.& Bickler, Philip E.& Lewin, Matthew R.. Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Journal of Tropical Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1202929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202929