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Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells
Joint Authors
Spassov, Sashko Georgiev
Kessler, Christoph
Jost, Rebecca
Schumann, Stefan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Protective mechanical ventilation is aimed at preventing ventilator-induced lung injury while ensuring sufficient gas exchange.
A new approach focuses on the temporal profile of the mechanical ventilation.
We hypothesized that the temporal mechanical strain profile modulates inflammatory signalling.
We applied cyclic strain with various temporal profiles to human bronchial epithelial cells (BEAS2B) and assessed proinflammatory response.
The cells were subjected to sinusoidal, rectangular, or triangular strain profile and rectangular strain profile with prestrain set to 0, 25, 50, or 75% of the maximum stain, static strain, and strain resembling a mechanical ventilation-like profile with or without flow-controlled expiration.
The BEAS2B response to mechanical load included altered mitochondrial activity, increased superoxide radical levels, NF-kappaB translocation, and release of interleukin-8.
The response to strain was substantially modulated by the dynamics of the stimulation pattern.
The rate of dynamic changes of the strain profile correlates with the degree of mechanical stress-induced cell response.
American Psychological Association (APA)
Spassov, Sashko Georgiev& Kessler, Christoph& Jost, Rebecca& Schumann, Stefan. 2019. Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202933
Modern Language Association (MLA)
Spassov, Sashko Georgiev…[et al.]. Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1202933
American Medical Association (AMA)
Spassov, Sashko Georgiev& Kessler, Christoph& Jost, Rebecca& Schumann, Stefan. Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1202933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202933