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Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis
Joint Authors
Figueredo-Silva, Jose
Norões, Joaquim
Dreyer, Gerusa
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
In endemic areas, lymphangiectasia is the fundamental alteration to live Wuchereria bancrofti adult worms which, in adult males, are usually found in the lymphatic vessels of the spermatic cord; accordingly, hydrocele/filaricele is the most common clinical manifestation of bancroftian filariasis.
The pathogenic role of the lymphatic endothelial cells (LECs) and the status of mesothelial cells (MCs) samples of the parietal layer (PL) of the tunica vaginalis testis were examined.
Methods.
The PL of thirty-two patients, excised for different reasons, was examined by histology and immunohistochemistry using the D2-40 monoclonal antibody for identification of LECs and CK-7 antibody for recognition of mesothelial cells (MCs).
Results.
The most important findings were (a) marked lymphangiectasia, especially in hydroceles with minor evolution time; (b) the first report of lymphatic stomata and submesothelial lacunae in filarial acute hydrocele; (c) the likely participation of LECs in filarial granuloma; (d) the potential phenotypic transition of LECs into myofibroblasts in severe chylocele; and (e) mesothelial reactive hyperplasia, a hallmark of filaricele, varying in intensity from mild to severe, sometimes mimicking a mesothelial neoplasia.
Conclusion.
The data suggest that LECs have an active role in the pathogenesis of bancroftian hydrocele and, possibly, in other clinical forms of lymphatic filariasis.
American Psychological Association (APA)
Figueredo-Silva, Jose& Norões, Joaquim& Dreyer, Gerusa. 2018. Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis. Journal of Tropical Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1202946
Modern Language Association (MLA)
Figueredo-Silva, Jose…[et al.]. Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis. Journal of Tropical Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1202946
American Medical Association (AMA)
Figueredo-Silva, Jose& Norões, Joaquim& Dreyer, Gerusa. Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis. Journal of Tropical Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1202946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202946