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The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing
Joint Authors
Prakoso, Yos Adi
Kurniasih, Siti Isrina Oktavia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study is to explore the effect of topical application of Aloe vera on skin wound healing.
Thirty-six male Sprague-Dawley rats weighing 150–200 grams were divided into four groups.
All groups were anesthetized, shaved, and exposed to round full-thickness punch biopsy on the back: group I (control); group II (treated with 1% Aloe vera cream); group III (treated with 2% Aloe vera cream); and group IV (treated with madecassol®).
The treatments were given once a day.
Macroscopic and microscopic examination were observed at 5, 10, and 15 days after skin biopsy.
Skin specimens were prepared for histopathological study using H&E stain and IHC stain against CD4+ and CD8+ lymphocytes.
All the data were analyzed using SPSS16.
The result showed that topical application of 1% and 2% Aloe vera cream significantly reduced the percentage of the wound, leucocytes infiltration, angiogenesis, and expression of CD8+ lymphocytes and increased the epidermal thickness and the expression of CD4+ lymphocytes (p ≤ 0,05).
There was no significant difference in the number of fibroblasts in all groups.
Topical application of 1% and 2% Aloe vera cream has wound healing potential via their ability to increase the ratio of CD4+/CD8+ lymphocytes in the wound area.
American Psychological Association (APA)
Prakoso, Yos Adi& Kurniasih, Siti Isrina Oktavia. 2018. The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing. Journal of Tropical Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1202966
Modern Language Association (MLA)
Prakoso, Yos Adi& Kurniasih, Siti Isrina Oktavia. The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing. Journal of Tropical Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1202966
American Medical Association (AMA)
Prakoso, Yos Adi& Kurniasih, Siti Isrina Oktavia. The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing. Journal of Tropical Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1202966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202966