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GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway
Joint Authors
Rong, Cuiping
Wang, Fugang
Liu, Xiaoqian
Sun, Yi
Hou, Xueqin
Zhang, Han-Ting
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ-aminobutyric acid (GABA) system in various brain structures.
GABAergic neurons have different subsets, some of which coexpress certain neuropeptides that can be found in the digestive system.
Accumulating evidence demonstrates that the gut-brain axis, which is primarily regulated by the vagus nerve, is involved in stress, suggesting a communication between the “gut-vagus-brain” pathway and the GABAergic neuronal system.
Here, we first summarize the evidence that the GABAergic system plays an essential role in stress responses.
In addition, we review the effects of stress on different brain regions and GABAergic neuron subpopulations, including somatostatin, parvalbumin, ionotropic serotonin receptor 5-HT3a, cholecystokinin, neuropeptide Y, and vasoactive intestinal peptide, with regard to signaling events, behavioral changes, and pathobiology of neuropsychiatric diseases.
Finally, we discuss the gut-brain bidirectional communications and the connection of the GABAergic system and the gut-vagus-brain pathway.
American Psychological Association (APA)
Hou, Xueqin& Rong, Cuiping& Wang, Fugang& Liu, Xiaoqian& Sun, Yi& Zhang, Han-Ting. 2020. GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway. Neural Plasticity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202972
Modern Language Association (MLA)
Hou, Xueqin…[et al.]. GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway. Neural Plasticity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1202972
American Medical Association (AMA)
Hou, Xueqin& Rong, Cuiping& Wang, Fugang& Liu, Xiaoqian& Sun, Yi& Zhang, Han-Ting. GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1202972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202972