Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes
Joint Authors
Antognazza, Maria Rosa
Abdel Aziz, Ilaria
Lodola, Francesco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Reactive Oxygen Species (ROS) play an essential dual role in living systems.
Healthy levels of ROS modulate several signaling pathways, but at the same time, when they exceed normal physiological amounts, they work in the opposite direction, playing pivotal functions in the pathophysiology of multiple severe medical conditions (i.e., cancer, diabetes, neurodegenerative and cardiovascular diseases, and aging).
Therefore, the research for methods to detect their levels via light-sensitive fluorescent probes has been extensively studied over the years.
However, this is not the only link between light and ROS.
In fact, the modulation of ROS mediated by light has been exploited already for a long time.
In this review, we report the state of the art, as well as recent developments, in the field of photostimulation of oxidative stress, from photobiomodulation (PBM) mediated by naturally expressed light-sensitive proteins to the most recent optogenetic approaches, and finally, we describe the main methods of exogenous stimulation, in particular highlighting the new insights based on optically driven ROS modulation mediated by polymeric materials.
American Psychological Association (APA)
Antognazza, Maria Rosa& Abdel Aziz, Ilaria& Lodola, Francesco. 2019. Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202976
Modern Language Association (MLA)
Antognazza, Maria Rosa…[et al.]. Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202976
American Medical Association (AMA)
Antognazza, Maria Rosa& Abdel Aziz, Ilaria& Lodola, Francesco. Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202976