Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort
Joint Authors
Aboud, Said
Mpembeni, Rose
Sylvester, Boniphace
Gasarasi, Dinah B.
Tarimo, Donath
Masawe, Siriel
Swedberg, Göte
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Infants born to mothers with placental malaria are prenatally exposed to Plasmodium falciparum antigens.
However, the effect of that exposure to subsequent immune responses has not been fully elucidated.
This study aimed at determining the effect of prenatal exposure to P.
falciparum on Interleukin-10 and Interferon-γ responses during clinical malaria episodes in the first 24 months of life.
Methods.
This prospective cohort study involved 215 infants aged 0-2 years born to mothers with or without placental malaria.
Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of IL-10 and IFN-γ in infants and detect IgM in cord blood.
Data were analyzed using SPSS version 20.
Findings.
Geometric mean for IFN-γ in exposed infants was 557.9 pg/ml (95% CI: 511.6-604.1) and in unexposed infants it was 634.4 pg/ml (95% CI: 618.2-668.5) (P=0.02).
Mean IL-10 was 22.4 pg/ml (95% CI: 19.4-28.4) and 15.1 pg/ml (95%CI: 12.4-17.6), respectively (P=0.01).
Conclusions.
Prenatal exposure to P.
falciparum antigens significantly affects IL-10 and IFN-γ responses during clinical malaria episodes in the first two years of life.
American Psychological Association (APA)
Sylvester, Boniphace& Gasarasi, Dinah B.& Aboud, Said& Tarimo, Donath& Masawe, Siriel& Mpembeni, Rose…[et al.]. 2018. Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort. Journal of Tropical Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1202980
Modern Language Association (MLA)
Sylvester, Boniphace…[et al.]. Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort. Journal of Tropical Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1202980
American Medical Association (AMA)
Sylvester, Boniphace& Gasarasi, Dinah B.& Aboud, Said& Tarimo, Donath& Masawe, Siriel& Mpembeni, Rose…[et al.]. Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort. Journal of Tropical Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1202980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202980