Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII

Joint Authors

Li, Shan
Mo, Yunchang
Chen, Na
Gu, Yixiao
Chen, Shuangdong
Tu, Yingying
Zhao, Xiaoyong
Yu, Qimin
Dai, Qinxue
Wang, Junlu

Source

Neural Plasticity

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-31

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology
Medicine

Abstract EN

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinase that is ubiquitously distributed in the central and peripheral nervous systems.

Moreover, its phosphorylated protein (P-CaMKII) is involved in memory, mood, and pain regulation in the anterior cingulate cortex (ACC).

Electroacupuncture (EA) is a traditional Chinese therapeutic technique that can effectively treat chronic inflammatory pain.

However, the CaMKII-GluA1 role in EA analgesia in the ACC remains unclear.

This study investigated the role of P-CaMKII and P-GluA1 in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA).

There were increased P-CaMKII and P-GluA1 levels in the ACC.

We found that intracerebroventricular injection of KN93, a CaMKII inhibitor, as well as EA stimulation, attenuated complete Freund’s adjuvant-induced pain behavior.

Further, EA increased pCaMKII-PICK1 complex (abbreviated as C-P complex) levels.

Our findings demonstrate that EA inhibits inflammatory pain by inhibiting CaMKII-GluA1 phosphorylation.

P-CaMKII is involved in EA analgesia as the pCaMKII-PICK1 complex.

American Psychological Association (APA)

Gu, Yixiao& Chen, Shuangdong& Mo, Yunchang& Tu, Yingying& Chen, Na& Li, Shan…[et al.]. 2020. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202997

Modern Language Association (MLA)

Li, Shan…[et al.]. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1202997

American Medical Association (AMA)

Gu, Yixiao& Chen, Shuangdong& Mo, Yunchang& Tu, Yingying& Chen, Na& Li, Shan…[et al.]. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202997

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1202997