Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII
Joint Authors
Li, Shan
Mo, Yunchang
Chen, Na
Gu, Yixiao
Chen, Shuangdong
Tu, Yingying
Zhao, Xiaoyong
Yu, Qimin
Dai, Qinxue
Wang, Junlu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinase that is ubiquitously distributed in the central and peripheral nervous systems.
Moreover, its phosphorylated protein (P-CaMKII) is involved in memory, mood, and pain regulation in the anterior cingulate cortex (ACC).
Electroacupuncture (EA) is a traditional Chinese therapeutic technique that can effectively treat chronic inflammatory pain.
However, the CaMKII-GluA1 role in EA analgesia in the ACC remains unclear.
This study investigated the role of P-CaMKII and P-GluA1 in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA).
There were increased P-CaMKII and P-GluA1 levels in the ACC.
We found that intracerebroventricular injection of KN93, a CaMKII inhibitor, as well as EA stimulation, attenuated complete Freund’s adjuvant-induced pain behavior.
Further, EA increased pCaMKII-PICK1 complex (abbreviated as C-P complex) levels.
Our findings demonstrate that EA inhibits inflammatory pain by inhibiting CaMKII-GluA1 phosphorylation.
P-CaMKII is involved in EA analgesia as the pCaMKII-PICK1 complex.
American Psychological Association (APA)
Gu, Yixiao& Chen, Shuangdong& Mo, Yunchang& Tu, Yingying& Chen, Na& Zhao, Xiaoyong…[et al.]. 2020. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202997
Modern Language Association (MLA)
Gu, Yixiao…[et al.]. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1202997
American Medical Association (AMA)
Gu, Yixiao& Chen, Shuangdong& Mo, Yunchang& Tu, Yingying& Chen, Na& Zhao, Xiaoyong…[et al.]. Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1202997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202997