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Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract
Joint Authors
Yoshida, Minoru
Xiang, Lan
Qi, Jianhua
Wu, Qiaobei
Cheng, Lihong
Sun, Kaiyue
Li, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Excessive food intake and metabolic disorder promote obesity and diabetes.
In China, peanut skin is used as a herbal medicine to treat hemophilia, thrombocytopenic purpura, and hepatic hemorrhage.
In the present study, we demonstrated that peanut skin extract (PSE) safely reduced appetite, body weight, fat tissue, plasma TG and TC, and blood glucose level in mice with diet-induced obesity (DIO).
Moreover, the leptin/leptin receptor/neuropeptide Y (NPY) and adiponectin signaling pathways involved in the antiobesity effects of PSE are confirmed through leptin and adiponectin overexpression and leptin receptor silencing in mice.
PSE consisted of oligosaccharide and polyphenol in a mass ratio of 45 : 55, and both parts were important for the antiobesity function of PSE.
Our results suggested that PSE can be developed as functional medical food to treat metabolic disorders and obesity.
American Psychological Association (APA)
Xiang, Lan& Wu, Qiaobei& Cheng, Lihong& Sun, Kaiyue& Li, Jing& Yoshida, Minoru…[et al.]. 2019. Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203006
Modern Language Association (MLA)
Xiang, Lan…[et al.]. Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203006
American Medical Association (AMA)
Xiang, Lan& Wu, Qiaobei& Cheng, Lihong& Sun, Kaiyue& Li, Jing& Yoshida, Minoru…[et al.]. Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203006