Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism
Joint Authors
Chang, Raymond Chuen-Chung
Chen, Zi-xian
Xu, Qing-qing
Shan, Chun-shuo
Shi, Yi-hua
Wang, Yong
Zheng, Guo-qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Borneol, a natural product in the Asteraceae family, is widely used as an upper ushering drug for various brain diseases in many Chinese herbal formulae.
The blood-brain barrier (BBB) plays an essential role in maintaining a stable homeostatic environment, while BBB destruction and the increasing BBB permeability are common pathological processes in many serious central nervous system (CNS) diseases, which is especially an essential pathological basis of cerebral ischemic injury.
Here, we aimed to conduct a systematic review to assess preclinical evidence of borneol for experimental ischemic stroke as well as investigate in the possible neuroprotective mechanisms, which mainly focused on regulating the permeability of BBB.
Seven databases were searched from their inception to July 2018.
The studies of borneol for ischemic stroke in animal models were included.
RevMan 5.3 was applied for data analysis.
Fifteen studies investigated the effects of borneol in experimental ischemic stroke involving 308 animals were ultimately identified.
The present study showed that the administration of borneol exerted a significant decrease of BBB permeability during cerebral ischemic injury according to brain Evans blue content and brain water content compared with controls (P<0.01).
In addition, borneol could improve neurological function scores (NFS) and cerebral infarction area.
Thus, borneol may be a promising neuroprotective agent for cerebral ischemic injury, largely through alleviating the BBB disruption, reducing oxidative reactions, inhibiting the occurrence of inflammation, inhibiting apoptosis, and improving the activity of lactate dehydrogenase (LDH) as well as P-glycoprotein (P-GP) and NO signaling pathway.
American Psychological Association (APA)
Chen, Zi-xian& Xu, Qing-qing& Shan, Chun-shuo& Shi, Yi-hua& Wang, Yong& Chang, Raymond Chuen-Chung…[et al.]. 2019. Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203019
Modern Language Association (MLA)
Chen, Zi-xian…[et al.]. Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1203019
American Medical Association (AMA)
Chen, Zi-xian& Xu, Qing-qing& Shan, Chun-shuo& Shi, Yi-hua& Wang, Yong& Chang, Raymond Chuen-Chung…[et al.]. Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203019