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Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia
Joint Authors
Sucipto, Teguh Hari
Kotaki, Tomohiro
Mulyatno, Kris Cahyo
Churrotin, Siti
Labiqah, Amaliah
Soegijanto, Soegeng
Kameoka, Masanori
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas.
Indonesia is one of the biggest dengue endemic countries in the world.
In the present study, the phylogenetic analysis of DENV in Bangkalan, Madura Island, Indonesia, was performed in order to obtain a clearer understanding of its dynamics in this country.
A total of 359 blood samples from dengue-suspected patients were collected between 2012 and 2014.
Serotyping was conducted using a multiplex Reverse Transcriptase-Polymerase Chain Reaction and a phylogenetic analysis of E gene sequences was performed using the Bayesian Markov chain Monte Carlo (MCMC) method.
17 out of 359 blood samples (4.7%) were positive for the isolation of DENV.
Serotyping and the phylogenetic analysis revealed the predominance of DENV-1 genotype I (9/17, 52.9%), followed by DENV-2 Cosmopolitan type (7/17, 41.2%) and DENV-3 genotype I (1/17, 5.9%).
DENV-4 was not isolated.
The Madura Island isolates showed high nucleotide similarity to other Indonesian isolates, indicating frequent virus circulation in Indonesia.
The results of the present study highlight the importance of continuous viral surveillance in dengue endemic areas in order to obtain a clearer understanding of the dynamics of DENV in Indonesia.
American Psychological Association (APA)
Sucipto, Teguh Hari& Kotaki, Tomohiro& Mulyatno, Kris Cahyo& Churrotin, Siti& Labiqah, Amaliah& Soegijanto, Soegeng…[et al.]. 2018. Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia. Journal of Tropical Medicine،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203025
Modern Language Association (MLA)
Sucipto, Teguh Hari…[et al.]. Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia. Journal of Tropical Medicine No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203025
American Medical Association (AMA)
Sucipto, Teguh Hari& Kotaki, Tomohiro& Mulyatno, Kris Cahyo& Churrotin, Siti& Labiqah, Amaliah& Soegijanto, Soegeng…[et al.]. Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia. Journal of Tropical Medicine. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203025