Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle
Joint Authors
Musarò, Antonio
Rizzuto, Emanuele
Forcina, Laura
Miano, Carmen
Berardinelli, Maria Grazia
De Benedetti, Fabrizio
Scicchitano, Bianca Maria
Pelosi, Laura
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The extent of oxidative stress and chronic inflammation are closely related events which coexist in a muscle environment under pathologic conditions.
It has been generally accepted that the inflammatory cells, as well as myofibers, are sources of reactive species which are, in turn, able to amplify the activation of proinflammatory pathways.
However, the precise mechanism underlining the physiopathologic interplay between ROS generation and inflammatory response has to be fully clarified.
Thus, the identification of key molecular players in the interconnected pathogenic network between the two processes might help to design more specific therapeutic approaches for degenerative diseases.
Here, we investigated whether elevated circulating levels of the proinflammatory cytokine Interleukin-6 (IL-6) are sufficient to perturb the physiologic redox balance in skeletal muscle, independently of tissue damage and inflammatory response.
We observed that the overexpression of circulating IL-6 enhances the generation and accumulation of free radicals in the diaphragm muscle of adult NSE/IL-6 mice, by deregulating redox-associated molecular circuits and impinging the nuclear factor erythroid 2-related factor 2- (Nrf2-) mediated antioxidant response.
Our findings are coherent with a model in which uncontrolled levels of IL-6 in the bloodstream can influence the local redox homeostasis, inducing the establishment of prooxidative conditions in skeletal muscle tissue.
American Psychological Association (APA)
Forcina, Laura& Miano, Carmen& Scicchitano, Bianca Maria& Rizzuto, Emanuele& Berardinelli, Maria Grazia& De Benedetti, Fabrizio…[et al.]. 2019. Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203040
Modern Language Association (MLA)
Forcina, Laura…[et al.]. Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1203040
American Medical Association (AMA)
Forcina, Laura& Miano, Carmen& Scicchitano, Bianca Maria& Rizzuto, Emanuele& Berardinelli, Maria Grazia& De Benedetti, Fabrizio…[et al.]. Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1203040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203040