Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy
Joint Authors
Zhang, Qiuyan
Lu, Yuting
Cheng, Peng
Zhang, Peng
Qian, Yangyan
Suo, Jinshuai
Zhu, Jing
Yang, Chao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect caused by chemotherapy drugs, and its existence seriously affects the quality of life of patients.
We first established an oxaliplatin-induced peripheral neuropathy (OIPN) model and then measured and evaluated mechanical hyperalgesia, thermal nociception, cold allodynia, and intraepidermal nerve fiber (IENF) density to determine Siwei Jianbu Decoction’s role in preventing OIPN.
Then, we conducted a systematic pharmacological study that revealed important roles for the MAPK signaling pathway and proinflammatory immune pathway and confirmed these roles by western blot, immunofluorescence, and qPCR.
The data show that Siwei Jianbu Decoction can effectively prevent oxaliplatin-induced neuroinflammation by inhibiting an increase in NF-κB expression via downregulation of p-ERK1/2 and p-p38.
The present study showed that SWJB may be beneficial in preventing oxaliplatin-induced peripheral neuropathy.
American Psychological Association (APA)
Zhang, Peng& Lu, Yuting& Yang, Chao& Zhang, Qiuyan& Qian, Yangyan& Suo, Jinshuai…[et al.]. 2020. Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203079
Modern Language Association (MLA)
Zhang, Peng…[et al.]. Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1203079
American Medical Association (AMA)
Zhang, Peng& Lu, Yuting& Yang, Chao& Zhang, Qiuyan& Qian, Yangyan& Suo, Jinshuai…[et al.]. Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1203079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203079