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The Outcome of Papillary Thyroid Cancer Associated with Graves’ Disease: A Case Control Study
Joint Authors
Menon, Riju
Nair, C. Gopalakrishnan
Babu, Misha
Jacob, Pradeep
Krishna, G. Praveen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Thyroidectomy is now a less popular therapeutic option for Graves’ disease.
The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves’ disease are controversial.
The outcome of thyroid cancers coexisting with Graves’ disease is debated.
Study Design.
Designed as retrospective case control study of papillary thyroid cancers associated with Graves’ disease and those with euthyroid background.
Pathological characteristics and outcome of papillary thyroid cancers in the two groups were compared.
Results.
The tumour characteristics did not differ significantly in the groups.
The patients were followed for a mean period of 77.32 months and found significant incidences of disease progression in patients with papillary thyroid cancer associated with Graves’ disease (p=0.034; OR 2.747, CI 1.078–7.004).
Disease progression as new distant metastases mostly in skeletal locations was high in this group compared to euthyroid group (p=0.027; OR 4.121, CI 1.008–15.600).
There was higher incidence of cumulative metastatic diseases in papillary thyroid cancer associated with Graves’ disease.
Conclusion.
Papillary thyroid cancers associated with Graves’ disease show aggressive biological behaviour and favoured site of distant metastases was osseous locations.
Early diagnosis by routine screening of Graves’ disease patients with ultrasound imaging and aspiration studies is recommended.
American Psychological Association (APA)
Menon, Riju& Nair, C. Gopalakrishnan& Babu, Misha& Jacob, Pradeep& Krishna, G. Praveen. 2018. The Outcome of Papillary Thyroid Cancer Associated with Graves’ Disease: A Case Control Study. Journal of Thyroid Research،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1203097
Modern Language Association (MLA)
Menon, Riju…[et al.]. The Outcome of Papillary Thyroid Cancer Associated with Graves’ Disease: A Case Control Study. Journal of Thyroid Research No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1203097
American Medical Association (AMA)
Menon, Riju& Nair, C. Gopalakrishnan& Babu, Misha& Jacob, Pradeep& Krishna, G. Praveen. The Outcome of Papillary Thyroid Cancer Associated with Graves’ Disease: A Case Control Study. Journal of Thyroid Research. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1203097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203097