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Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Joint Authors
Shang, Peng
Lv, Huanhuan
Zhen, Chenxiao
Liu, Junyu
Yang, Pengfei
Hu, Lijiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG).
The processes of glutathione synthesis, transport, utilization, and metabolism are tightly controlled to maintain intracellular glutathione homeostasis and redox balance.
As for cancer cells, they exhibit a greater ROS level than normal cells in order to meet the enhanced metabolism and vicious proliferation; meanwhile, they also have to develop an increased antioxidant defense system to cope with the higher oxidant state.
Growing numbers of studies have implicated that altering the glutathione antioxidant system is associated with multiple forms of programmed cell death in cancer cells.
In this review, we firstly focus on glutathione homeostasis from the perspectives of glutathione synthesis, distribution, transportation, and metabolism.
Then, we discuss the function of glutathione in the antioxidant process.
Afterwards, we also summarize the recent advance in the understanding of the mechanism by which glutathione plays a key role in multiple forms of programmed cell death, including apoptosis, necroptosis, ferroptosis, and autophagy.
Finally, we highlight the glutathione-targeting therapeutic approaches toward cancers.
A comprehensive review on the glutathione homeostasis and the role of glutathione depletion in programmed cell death provide insight into the redox-based research concerning cancer therapeutics.
American Psychological Association (APA)
Lv, Huanhuan& Zhen, Chenxiao& Liu, Junyu& Yang, Pengfei& Hu, Lijiang& Shang, Peng. 2019. Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203098
Modern Language Association (MLA)
Lv, Huanhuan…[et al.]. Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203098
American Medical Association (AMA)
Lv, Huanhuan& Zhen, Chenxiao& Liu, Junyu& Yang, Pengfei& Hu, Lijiang& Shang, Peng. Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203098